Edition Updates: The book has undergone five updates in the last 28 years, indicating its enduring popularity and relevance. The release of a new sixth edition is encouraged. • Drug Landscape Changes: Many new drugs have been introduced, popular brands discontinued, and outdated drugs replaced with new therapies. The revised edition reflects these changes. • Focus on COVID-19: The book adequately covers clinical aspects of COVID-19, including presentation, investigations, complications, treatment, and vaccination. • Inclusion of Surgical Problems: A new chapter addressing surgical problems in general practice has been introduced in this new edition. • Expanded Appendices: Additional appendices have been added, covering topics such as current trends in bronchial asthma, bronchial asthma in general practice, neonatology and homeopathy, Ayurveda in pediatric dermatology, and nutritional supplements in pediatrics according to Ayurveda. • Holistic Approach: The book includes chapters on Ayurvedic medicines, homeopathic remedies, and common dental illnesses, providing a holistic view of medical practices. • Vaccination Updates: Chapters on vaccination for children and adults are updated, along with coverage of the National Tuberculosis Prevention Programme and National Deworming Day in the context of preventive medicine. • Author’s Experience: The revision draws from 41 years of the author’s general practice experience across various societal strata, making the book a practical and widely used resource for General Practitioners of different medical approaches. • This comprehensive update suggests that the book aims to be a reliable and up-to-date reference for practitioners across different medical specialties